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Network Bioinformatics

Biological processes in the live cycle of a cell such as proliferation, signal transduction or apoptosis are shaped by proteins interacting specifically with each other and building more or less transient complexes. To understand these processes, determining the underlying protein interactions is of vital importance. In recent years, high-throughput methods such as yeast two-hybrid (Y2H) and tandem affinity purification (TAP) have made it possible to determine protein interactions on a large scale. As a consequence, species-specific interaction networks have been and are still determined for a range of organisms.

We develop methods and provide assistance for the analysis of large-scale interaction networks determined, e.g. by yeast two-hybrid, the identification of protein complexes and their substructures from affinity purification experiments and the extraction of known interactions from literature.

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