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Structural Bioinformatics

Since it is the structure of a protein which finally accounts for the distinct functional properties like enzymatic reaction mechanisms and the specificity of protein-protein interactions those can only be understood in detail on the structure level. Novel developments in genome sequencing techniques and experimental biology have led to an exponential increase in the number of known protein sequences (for which no protein structures are available) but also to an strong (nevertheless much slower) increase of available protein structures in the last years. In order to assign many protein sequences with unknown structures to their potential structures based on involved sequence comparison techniques and also to analyze existing protein structures and their relationships in more detail, we have developed a large set of methods, databases and software tools.


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