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Quasar - Scoring and Ranking of Sequence-Structure Alignments


With the growing gap between the number of known protein sequences in databases like SwissProt/TrEMBL and the number of experimentally determined protein structures in the PDB, automated structure prediction methods like homology modeling and fold recognition have become valuable tools for assigning potential folds to new protein sequences. A wide range of structure prediction servers is available on the web that offer a variety of possibilities for generating structural alignments of a query protein to a template protein with known 3D structure. Nevertheless, identifying the "best" structural alignment in a set of sequence-structure alignments (possibly coming from different sources) remains a difficult task.


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